Michael Scofield (Wentworth Miller) / Staffel 1 & 2 Lincoln Burrows (Dominic Purcell) / Staffel 1 & 2 Sucre (Amaury Nolasco) / Staffel 1 & 2 Dr. Sara Tancredi (Sarah Wayne Callies) / Staffel 1 & 2 Theodore "T-Bag" Bagwell (Robert Knepper) / Staffel 1 & 2 John Abruzzi (Peter Stormare) / Staffel 1 & 2 Benjamin Miles "C-Note" Franklin (Rockmund Dunbar) / Staffel 1 & 2 David "Tweener" Apolskis (Lane Garrison) / Staffel 1 & 2 Charles "Haywire" Patoshik (Silas Weir Mitchell) / Staffel 1 & 2 Charles Westmoreland (Muse Watson) / Staffel 1 Captain Brad Bellick (Wade Williams) / Staffel 1 & 2 Gefängnisdirektor Henry Pope (Stacey Keach) / Staffel 1 Veronica Donovan (Robin Tunney) / Staffel 1 Nick Savrinn (Frank Grillo) / Staffel 1 Lincoln "L.J." Burrows, junior (Marshall Allman) / Staffel 1 Agent Paul Kellerman (Paul Adelstein) / Staffel 1 & 2 Maricruz Delgado (Camille Guaty) / Staffel 1 Nika Volek (Holly Valance) / Staffel 1 Agent Alexander Mahone (William Fichtner) / Staffel 2